The efficacy of oral Micronized Progesterone versus Medroxyprogesterone Acetate in the control of mild to moderate abnormal uterine bleeding &ndash; ovulatory Dysfunction (AUB-O) in Adolescents: An Open Label Randomized Controlled Trial

Angeline  G. Santos,; Mary  Carmona-Tan,; Ma. Socorro  C. Bernardino,

The efficacy of oral Micronized Progesterone versus Medroxyprogesterone Acetate in the control of mild to moderate abnormal uterine bleeding – ovulatory Dysfunction (AUB-O) in Adolescents: An Open Label Randomized Controlled Trial

Angeline G Santos | Mary Carmona-Tan | Ma. Socorro C Bernardino

Abstract:

OBJECTIVES: To determine the efficacy of micronized oral progesterone (OMP) versus Medroxyprogesterone Acetate (MPA) in the control and regulation of mild to moderate abnormal uterine bleeding in adolescents with ovulatory dysfunction. MATERIALS AND METHODS: This is an open labelled Randomized Controlled Trial. Fifty patients with mild to moderate abnormal uterine bleeding were randomized to treatment with Medroxyprogesterone Acetate or Oral Micronized Progesterone. RESULTS: There was no significant difference in the control of bleeding for patients with moderate abnormal bleeding. There was no significant difference in the regularity of cycles and length of bleeding once the patients were started on cyclic dosing. There was a difference in amount of bleeding (1-3 pads versus 2-4 pads for MPA and OMP respectively), but both were within normal amount. The adverse effects experienced for patients taking OMP was significantly more compared to MPA. CONCLUSION: Oral Micronized Progesterone is just as effective as Medroxyprogesterone Acetate in the control and regulation of mild to moderate abnormal uterine bleeding in adolescents with ovulatory dysfunction. However, it was associated with more adverse effects.

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